Chronic Spontaneous Urticaria – the Saskatchewan experience and questionnaire survey

Results In the original cohort there were significantly more females than males (130:43). The ASST was positive in 58 patients (42.02%), and only a quarter of these were men (M: F; 12:46). Of the respondents, 80 were women and 21 men. The age range was 1 year to 81. The mean age was 36 years. The average duration of symptoms was 9.3 years. They included 40 patients who were ASST positive (M: F; 8:32) and 49 negative M:F; 12:37 ). 50 participants no longer had hives. Patients reported being most bothered by pruritus, disturbed sleep, anxiety and their physical appearance including facial swelling. Many (71.2%) had missed work or school because of the urticaria. Almost 22% of participants attributed stress to be a major cause of their CSU. Twenty-nine patients found antihistamines alone gave adequate relief of urticaria. Prednisone, as prescribed by emergency room physicians and family practitioners, was added as treatment in about a fifth of all the participants. Twenty ASST positive patients with severe uncontrollable hives were treated with intravenous immunoglobulin (IVIG) available to the patients at no cost through Canadian Blood Transfusion Services. 85.0% of these patients had improved quality of life, with 13 of these patients were now free of urticaria and no longer receiving IVIG. Three patients who did not benefit from IVIG did respond to methotrexate. None of the ASST negative patients received IVIG.